Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration
Calcium independent group VIA phospholipase A2 (iPLA2β) and Matrix Metalloproteinase-9 (MMP-9) are upregulated in many disease states; their involvement with cancer cell migration has been a recent subject for study. Further, the molecular mechanisms mediating nicotine-induced breast cancer cell progression have not been fully investigated. This study aims to investigate whether iPLA2β mediates nicotine-induced breast cancer cell proliferation and migration through both in-vitro and in-vivo techniques. Subsequently, the ability of Bromoenol Lactone (BEL) to attenuate the severity of nicotine-induced breast cancer was examined.
Calderon, L. E., Liu, S., Arnold, N., Breakall, B., Rollins, J., & Ndinguri, M. (2015). Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration. PLOS ONE PLoS ONE, 10(11). doi:10.1371/journal.pone.0143277