EKU Faculty and Staff Scholarship
 

Department

Chemistry

Document Type

Article

Publication Date

6-2016

Abstract

Reactive oxygen species (ROS) are an unavoidable byproduct of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a long time ROS were thought to cause exclusively toxic effects which were associated with various pathologies, including carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, to date, it is known that while prolonged exposure to high ROS concentrations may lead to various disorders, low ROS concentrations exert beneficial effects regulating cell signaling cascades.

Journal Title

Oxidative Medicine and Cellular Longevity

Journal Volume

2016

Included in

Chemistry Commons

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