Sergio Di Meo, Tanea T. Reed, Paola Venditti, and Victor M. Victor, “Harmful and Beneficial Role of ROS,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 7909186, 3 pages, 2016. doi:10.1155/2016/7909186
Reactive oxygen species (ROS) are an unavoidable byproduct of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a long time ROS were thought to cause exclusively toxic effects which were associated with various pathologies, including carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, to date, it is known that while prolonged exposure to high ROS concentrations may lead to various disorders, low ROS concentrations exert beneficial effects regulating cell signaling cascades.
Oxidative Medicine and Cellular Longevity