Beginning in the Renaissance and following through the Classical and Baroque eras, the Italian Ospedali aided in the spread and practice of Italian music while benefitting all who participated. In this presentation, there is a discussion of the economic, social and cultural reasons these institutions developed, how music training was taught and how it affected the orphans, as well as other institutions that have similar goals today. This integrative review uses information from numerous sources to describe and demonstrate the positive impact music can have on at-risk populations.The Ospedali gave orphans an opportunity to grow and become functional members of society through educating them in a trade that would turn into a career as they transitioned to adulthood. The Ospedali offered music programs to its girl students, which gave them the opportunity to learn music from famous teachers, performers, and composers using state of the art instruments, and perform for crowds of people of all classes. The music programs in the Venetian and Florentine Ospedali brought fame, recognition, and tourism to Italy which helped the economies of the communities each Ospedali resided in. Modern-day foundations and organizations with goals similar to the Italian Ospedali have proven to be just as successful economically, culturally, and socially, by continuing a legacy of love and passion for music and fostering a positive environment for those less fortunate.