Abstract

Histology is the study of microscopic tissue structures that examines the correlation between structure and function. This technique was utilized when analyzing the biological processes of folliculogenesis and oogenesis. These processes study the maturation of the ovarian follicle and production of an ovum, respectively. The p75 neurotrophin receptor (p75NTR)has been identified to contribute to the maturation of ovarian follicles, but the role of p75NTR in ovulation remains unknown. To investigate the role of p75NTR in ovulation, an animal study analyzing the histology of the mouse ovary was conducted. In this study, the number of primary follicles, secondary follicles, antral follicles, and corpus luteum were analyzed in wild type mice and then compared to the follicles present in genetically modified mice that lacked the p75NTRgene (p75 knock out (p75KO) mice). When the mice in this study reached eight weeks of age, the mice were killed, and their reproductive tissues were collected. Upon harvest, the tissues were processed for sectioning and then stained for analysis. Microscopic analysis revealed that there was a significant relationship between the number of corpus luteum present in the wild type mice compared to the knockout mice (p=0.006). Indicating that wildtype mice are ovulating at higher rates than p75KO mice. This data supports that p75NTR is playing an active role in the ovulatory process.

Semester/Year of Award

Fall 2020

Mentor

Oliver Oakley

Mentor Department Affiliation

Biological Sciences

Mentor Professional Affiliation

Dr. Oliver Oakley

Access Options

Open Access Thesis

Degree Name

Honors Scholars

Degree Level

Bachelors

Department

Biological Sciences

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