University Presentation Showcase: Graduate Division

Project Title

Spectroscopic and Chromatographic Studies on Some Regioisomeric Aromatase Inhibitors

Presenter Hometown

Versailles, Ky

Major

Chemistry

Department

Chemistry

Degree

Graduate

Mentor

Karim Abdelhay

Mentor Department

Chemistry

Abstract

The broad objective of this research is to improve the specificity, selectivity and reliability of the analytical methods used to identify three regioisomeric aromatase inhibitors; 5-alpha-Androstan-17-one, 5-alpha-Androst-16-en-3alpha-ol, and 17-beta-Hydroxy-5-alpha-androst-2-ene. A combination of chromatographic and spectroscopic techniques namely, HPLC, GC-MS, and FT-IR, will be used to generate the analytical profiles of the three regioisomeric drugs in addition to discriminating among them. In addition, this project is aiming to improve chromatographic resolution between the three studies compounds to provide additional layer of discrimination when the mass spectra are nearly identical.

Presentation format

Poster

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Spectroscopic and Chromatographic Studies on Some Regioisomeric Aromatase Inhibitors

The broad objective of this research is to improve the specificity, selectivity and reliability of the analytical methods used to identify three regioisomeric aromatase inhibitors; 5-alpha-Androstan-17-one, 5-alpha-Androst-16-en-3alpha-ol, and 17-beta-Hydroxy-5-alpha-androst-2-ene. A combination of chromatographic and spectroscopic techniques namely, HPLC, GC-MS, and FT-IR, will be used to generate the analytical profiles of the three regioisomeric drugs in addition to discriminating among them. In addition, this project is aiming to improve chromatographic resolution between the three studies compounds to provide additional layer of discrimination when the mass spectra are nearly identical.