Title

Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration

Authors

Lindsay Calderon, Eastern Kentucky UniversityFollow
Shu Liu, Hebei University Health Science
Nova Arnold, Eastern Kentucky University
Bethanyl Breakal, Eastern Kentucky University
Joseph Rollins, Eastern Kentucky University
Margaret Ndinguri, Eastern Kentucky UniversityFollow

Author ORCID Identifier

Lindsay Calderon https://orcid.org/0000-0003-0919-0077

Department

Biological Sciences

Document Type

Article

Publication Date

11-2015

Abstract

Calcium independent group VIA phospholipase A₂ (iPLA₂β) and Matrix Metalloproteinase-9 (MMP-9) are upregulated in many disease states; their involvement with cancer cell migration has been a recent subject for study. Further, the molecular mechanisms mediating nicotine-induced breast cancer cell progression have not been fully investigated. This study aims to investigate whether iPLA₂β mediates nicotine-induced breast cancer cell proliferation and migration through both in-vitro and in-vivo techniques. Subsequently, the ability of Bromoenol Lactone (BEL) to attenuate the severity of nicotine-induced breast cancer was examined.

Journal Title

PLOS One

Recommended Citation

Calderon, L. E., Liu, S., Arnold, N., Breakall, B., Rollins, J., & Ndinguri, M. (2015). Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration. PLOS ONE PLoS ONE, 10(11). doi:10.1371/journal.pone.0143277