Title

Smooth Muscle-specific Expression of Calcium-independent Phospholipase A2 (iPLA2 ) Participates in the Initiation and Early Progression of Vascular Inflammation and Neointima Formation

Authors

Shu Liu, Capital Medical University
Zhongwen Xie, University of Kentucky
Qingwei David Zhao, University of Texas Health Science Center, San Antonio
Huan Pang, University of Kentucky
John Turk, Washington University, St. Louis
Lindsay E. Cormier, Eastern Kentucky UniversityFollow
Wen Su, Chinese Academy of Sciences
Guogang Zhao, University of Kentucky
Haifei Xu, University of Kentucky
Ming Gong, Beijing Normal University,
Zhenheng Guo, Eastern Kentucky University

Author ORCID Identifier

Lindsay Calderon https://orcid.org/0000-0003-0919-0077

Department

Biological Sciences

Document Type

Article

Publication Date

5-2012

Abstract

Background: The role of iPLA 2 β as a regulator of inflammatory signaling and neointima formation is unknown.

Result: Smooth muscle-specific expression of iPLA 2 β exacerbates proinflammatory cytokine production, macrophage infiltration, and neointima formation.

Conclusion: Smooth muscle-specific iPLA 2 β participates in the initiation and early progression of vascular inflammation and neointima formation.

Significance: iPLA 2 β may represent a novel therapeutic target for attenuating vascular inflammation and restenosis.

Journal Title

Journal of Biological Chemistry

Recommended Citation

Liu, S., Xie, Z., Zhao, Q., Pang, H., Turk, J., Calderon, L., . . . Guo, Z. (2012). Smooth Muscle-specific Expression of Calcium-independent Phospholipase A2 (iPLA2 ) Participates in the Initiation and Early Progression of Vascular Inflammation and Neointima Formation. Journal of Biological Chemistry, 287(29), 24739-24753. doi:10.1074/jbc.m112.340216