Background: The role of iPLA 2 β as a regulator of inflammatory signaling and neointima formation is unknown.
Result: Smooth muscle-specific expression of iPLA 2 β exacerbates proinflammatory cytokine production, macrophage infiltration, and neointima formation.
Conclusion: Smooth muscle-specific iPLA 2 β participates in the initiation and early progression of vascular inflammation and neointima formation.
Significance: iPLA 2 β may represent a novel therapeutic target for attenuating vascular inflammation and restenosis.
Liu, S., Xie, Z., Zhao, Q., Pang, H., Turk, J., Calderon, L., . . . Guo, Z. (2012). Smooth Muscle-specific Expression of Calcium-independent Phospholipase A2 (iPLA2 ) Participates in the Initiation and Early Progression of Vascular Inflammation and Neointima Formation. Journal of Biological Chemistry, 287(29), 24739-24753. doi:10.1074/jbc.m112.340216