Harmful and Beneficial Role of ROS

Authors

Sergio Di Meo, Università di Napoli
Tanea Reed, Eastern Kentucky UniversityFollow
Paola Venditti, Università di Napoli
Victor M. Victor, Dr. Peset University Hospital, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region

Author ORCID Identifier

Tanea Reedhttps://orcid.org/0000-0003-2642-3100

Department

Chemistry

Document Type

Article

Publication Date

6-2016

Abstract

Reactive oxygen species (ROS) are an unavoidable byproduct of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a long time ROS were thought to cause exclusively toxic effects which were associated with various pathologies, including carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, to date, it is known that while prolonged exposure to high ROS concentrations may lead to various disorders, low ROS concentrations exert beneficial effects regulating cell signaling cascades.

Recommended Citation

Sergio Di Meo, Tanea T. Reed, Paola Venditti, and Victor M. Victor, “Harmful and Beneficial Role of ROS,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 7909186, 3 pages, 2016. doi:10.1155/2016/7909186

Journal Title

Oxidative Medicine and Cellular Longevity