Lipid peroxidation and neurodegenerative disease
Author ORCID Identifier
Tanea Reedhttps://orcid.org/0000-0003-2642-3100
Department
Chemistry
Document Type
Article
Publication Date
10-1-2011
Abstract
Lipid peroxidation is a complex process involving the interaction of oxygen-derived free radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic aldehydes. Since 1975, lipid peroxidation has been extensively studied in a variety of organisms. As neurodegenerative diseases became better understood, research establishing a link between this form of oxidative damage, neurodegeneration, and disease has provided a wealth of knowledge to the scientific community. With the advent of proteomics in 1995, the identification of biomarkers for neurodegenerative disorders became of paramount importance to better understand disease pathogenesis and develop potential therapeutic strategies. This review focuses on the relationship between lipid peroxidation and neurodegenerative diseases. It also demonstrates how findings in current research support the common themes of altered energy metabolism and mitochondrial dysfunction in neurodegenerative disorders.
Recommended Citation
Reed, Tanea T., "Lipid peroxidation and neurodegenerative disease" (2011). EKU Faculty and Staff Scholarship. 638.
https://encompass.eku.edu/fs_research/638
Journal Title
Free Radical Biology and Medicine