University Presentation Showcase: Graduate Division

Project Title

CHROMATOGRAPHIC STUDIES OF SOME HORMONE AND METABOLIC MODULATORS USED FOR DOPING IN SPORTS

Presenter Hometown

Jerseyville, IL

Major

Chemistry

Department

Chemistry

Degree

Graduate

Mentor

Dr. Karim Abdelhay

Mentor Department

Chemistry

Abstract

The World Anti-Doping Agency’s (WADA) mission is “to lead a collaborative worldwide movement for doping-free sport” (WADA). For this mission, the WADA needs quick and accurate methods for analyzing athletes’ biological fluids for possible performance enhancing drugs (PEDs). Doping began as early as the third century, through various remedies to enhance athletic performance; despite its early appearance, the ban of doping for athletes internationally did not start until 1928. Testing and disqualifications for the use of PEDs were not possible until the Olympics in 1968.

This research will focus on the analysis of a type of hormone and metabolic modulator known as selective estrogen receptor modulators (SERMs); these PEDs have been preferred over anabolic steroids because they exclude obvious symptoms of abuse like gynecomastia (growth of breast tissue in males). They do have a number of medical uses, such as the treatment of breast cancer and osteoporosis; however, the WADA bans them because SERMs increase the testosterone levels in the body. There is currently little research of using gas chromatography-mass spectroscopy (GCMS) for the analysis of SERMs. This research is primarily focused on developing and validating simple, sensitive, rapid and economic GC-MS analytical methods for determination of SERMs and other PEDs in bulk and in biological fluids.

Presentation format

Poster

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CHROMATOGRAPHIC STUDIES OF SOME HORMONE AND METABOLIC MODULATORS USED FOR DOPING IN SPORTS

The World Anti-Doping Agency’s (WADA) mission is “to lead a collaborative worldwide movement for doping-free sport” (WADA). For this mission, the WADA needs quick and accurate methods for analyzing athletes’ biological fluids for possible performance enhancing drugs (PEDs). Doping began as early as the third century, through various remedies to enhance athletic performance; despite its early appearance, the ban of doping for athletes internationally did not start until 1928. Testing and disqualifications for the use of PEDs were not possible until the Olympics in 1968.

This research will focus on the analysis of a type of hormone and metabolic modulator known as selective estrogen receptor modulators (SERMs); these PEDs have been preferred over anabolic steroids because they exclude obvious symptoms of abuse like gynecomastia (growth of breast tissue in males). They do have a number of medical uses, such as the treatment of breast cancer and osteoporosis; however, the WADA bans them because SERMs increase the testosterone levels in the body. There is currently little research of using gas chromatography-mass spectroscopy (GCMS) for the analysis of SERMs. This research is primarily focused on developing and validating simple, sensitive, rapid and economic GC-MS analytical methods for determination of SERMs and other PEDs in bulk and in biological fluids.