University Presentation Showcase: Graduate Poster Gallery
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Creation Date
2021
Major
Chemistry
Department
Chemistry
Degree
Graduate
Mentor
Karim Abdelhay
Mentor Department
Chemistry
Abstract
The broad objective of this research is to improve the specificity, selectivity and reliability of the analytical methods used to identify three regioisomeric aromatase inhibitors; 5-alpha-Androstan-17-one, 5-alpha-Androst-16-en-3a-ol and 17-beta-Hydroxy-5-alpha-androst-2-ene. A combination of chromatographic and spectroscopic techniques namely, HPLC, GC-MS, and FT-IR, will be used to generate the analytical profiles of the three regioisomeric drugs in addition to discriminating among them. In addition, this project is aiming to improve chromatographic resolution between the three studies compounds to provide additional layer of discrimination when the mass spectra are nearly identical.
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