Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration

Authors

Lindsay Calderon, Eastern Kentucky UniversityFollow
Shu Liu
Nova Arnold
Bethany Breakall
Joseph Rollins
Margaret Ndinguri

Author ORCID Identifier

Lindsay Calderonhttps://orcid.org/0000-0003-0919-0077

Department

Biological Sciences

Document Type

Article

Publication Date

11-20-2015

Abstract

Calcium independent group VIA phospholipase A2 (iPLA2β) and Matrix Metalloproteinase-9 (MMP-9) are upregulated in many disease states; their involvement with cancer cell migration has been a recent subject for study. Further, the molecular mechanisms mediating nicotine-induced breast cancer cell progression have not been fully investigated. This study aims to investigate whether iPLA2β mediates nicotine-induced breast cancer cell proliferation and migration through both in-vitro and in-vivo techniques. Subsequently, the ability of Bromoenol Lactone (BEL) to attenuate the severity of nicotine-induced breast cancer was examined.

Recommended Citation

Calderon, Lindsay; Liu, Shu; Arnold, Nova; Breakall, Bethany; Rollins, Joseph; and Ndinguri, Margaret, "Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration" (2015). EKU Faculty and Staff Scholarship. 531.
https://encompass.eku.edu/fs_research/531

Journal Title

Plos One